Far into the future in 2100, the human population has dropped rapidly. Fearing the complete extinction of humanity, a country runs a human production factory and raising newborn infants in incubators. Yeo Miro meets Jeong Da-jeong and falls in love with him. After, he looks back on his life growing up in an incubator and feels the affection of a large family.
Set in both Seoul, South Korea and Wetzlar, Germany, "Lotte Haus" follows Suji, an aspiring actress, as she searches for her missing purse while on a location scout in Wetzlar. The tale becomes more harrowing for Suji as Goethe's Charlotte and her own life begin to merge into one. Will her story end as Charlotte's did in Goethe's novel?